On the Anomalous Activity of Thyroxin Analogs in Tadpoles

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Science  12 May 1961:
Vol. 133, Issue 3463, pp. 1487-1489
DOI: 10.1126/science.133.3463.1487


The abnormally high thyroxin-like activity of certain thyroxin analogs is due to the use of the unique test route of immersion. When thyroxin, triiodothyronine, and their propionic and acetic acid analogs are tested by injection into the tadpole, their activities are more comparable to activity levels established in rat and man.