Sparing of Folinic Acid by Thymidine

Science  02 Jun 1961:
Vol. 133, Issue 3466, pp. 1773
DOI: 10.1126/science.133.3466.1773


Thymidine, which is inactive when added alone to Pediococcus cerevisiae (Leuconostoc citrovorum) 8081, was found to increase its growth in the presence of folinic acid. The addition of thymidine increased both the sensitivity of the folinic acid assay and the total growth yield. The mechanism of the synergistic effect of thymidine is briefly discussed.