Role for Ganglionic Norepinephrine in Sympathetic Synaptic Transmission

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Science  09 Jun 1961:
Vol. 133, Issue 3467, pp. 1822-1823
DOI: 10.1126/science.133.3467.1822


Transmission of nerve impulses in superior cervical sympathetic ganglia of cats and rabbits is markedly enhanced after reserpine-induced depletion of ganglionic norepinephrine. Transmission is also enhanced by administration of adrenergic blocking agents. In contrast, reserpine-induced release of ganglionic norepinephrine in animals pretreated with a monoamine oxidase inhibitor results in a pronounced depression of ganglionic transmission, which lasts until the ganglionic norepinephrine disappears. These results support the concept that norepinephrine in ganglia modulates the action of acetylcholine.