Instrumental Conditioning of Jugular Self-Infusion in the Rhesus Monkey

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Science  09 Jun 1961:
Vol. 133, Issue 3467, pp. 1829-1830
DOI: 10.1126/science.133.3467.1829


A technique is described for self-infusion of pharmacologic agents in solution through a permanently indwelling jugular catheter in the rhesus monkey. The results of an experiment utilizing this technique demonstrate that an instrumental lever response can be conditioned, extinguished, reconditioned, and brought under stimulus control and reward-schedule control with saline self-infusion as the reinforcing stimulus.