Indole-like Urinary Stress Reactant in Man

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Science  09 Jun 1961:
Vol. 133, Issue 3467, pp. 1832-1833
DOI: 10.1126/science.133.3467.1832


Paper chromatograms on extracts from serial 6-hr urine samples from humans of both sexes on indole-controlled diets revealed either the appearance of or marked increment in "spot 32" (1) after ACTH gel injections. This corresponds in time and duration with the rise in 17-hydroxycorticoid excretion. 5-Hydroxyindoleacetic acid and 28 other urinary indoles failed to show this rise predictably.