Vitamin B12 Requirement of a Marine Blue-Green Alga

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Science  16 Jun 1961:
Vol. 133, Issue 3468, pp. 1922-1923
DOI: 10.1126/science.133.3468.1922


A species of Synechocystis isolated from a marine mud has an absolute requirement for vitamin B12. Analogues of B12, including cobinamide and α-(adenyl) cobamide cyanide, satisfactorily substitute for vitamin B12. Methionine alone or in combination with other compounds supports only a low level of growth.