Quantal and Graded Analysis of Dosage-Effect Relations

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Science  16 Jun 1961:
Vol. 133, Issue 3468, pp. 1924-1925
DOI: 10.1126/science.133.3468.1924


Loewe's recommendations regarding treatment of stimulus-response relations are criticized. Conditions are described where quantal analysis is justified. Loewe's interpretation of his graded analysis must be modified in the light of the fact that response curves for individuals frequently cross. Superior lines of attack on the problem are suggested.