Inhibiting Effect of Tobacco Smoke on Some Crystalline Enzymes

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Science  07 Jul 1961:
Vol. 134, Issue 3471, pp. 52-53
DOI: 10.1126/science.134.3471.52


Tobacco smoke absorbed in phosphate buffer at neutral pH inhibits irreversibly the enzymes rabbit muscle glyceraldehyde-3-phosphate dehydrogenase and yeast alcohol dehydrogenase, whereas lactic dehydrogenase and glutamic dehydrogenase are not inhibited. A transient inhibition of beef liver catalase occurs. Indirect evidence suggests that the observed enzyme inhibition is caused by peroxides present in the smoke.