Variable Expressivity of a Mutant Gene in Leopard Frog

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Science  14 Jul 1961:
Vol. 134, Issue 3472, pp. 102-104
DOI: 10.1126/science.134.3472.102


The genetic distinction between the nonspotted, or burnsi, mutant and the common-spotted, wild-type leopard frog is not simply unifactorial. The burnsi phenotype is a manifestation of genic interaction between a major pigmentary locus and a complex of modifiers (minor genes with small effects).