Acid-Catalyzed Oxidation of Reduced Pyridine Nucleotides

Science  28 Jul 1961:
Vol. 134, Issue 3474, pp. 280-281
DOI: 10.1126/science.134.3474.280-a


Reduced pyridine nucleotides are oxidatively catalyzed in weakly acidic solutions. The rate is proportional to the acidity, and at constant acidic pH, the reaction follows first-order kinetics. The rate of oxidation of reduced triphosphopyridine nucleotide is approximately 3 times that of reduced diphosphopyridine nucleotide. The reaction offers a very plausible explanation for the metabolic efficiency of the malignant tumor cell. It may also play a key role in wound healing and muscle contraction.