Reaction of Human Sera with Mammalian Chromosomes Shown by Fluorescent Antibody Technique

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Science  28 Jul 1961:
Vol. 134, Issue 3474, pp. 284-286
DOI: 10.1126/science.134.3474.284-a


Certain human sera, including sera from five patients with lupus erythematosus, react with mammalian chromosomes. If chromosomal preparations are exposed first to the serum and then to horse antihuman globulin conjugated with fluorescein, the chromosomes will fluoresce. Sera having this activity appear to react with all the chromosomes of the cell.