Possible Mode of Antidepressive Action of Imipramine

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Science  28 Jul 1961:
Vol. 134, Issue 3474, pp. 286-287
DOI: 10.1126/science.134.3474.286


Imipramine augmented and prolonged methamphetamine-induced increases in the rate of responding of rats working for "rewarding" hypothalamic and midbrain stimulation. In contrast, chlorpromazine antagonized the effects of methamphetamine on self-stimulation. These opposite psychopharmacological effects are consistent with the different clinical effects of these drugs and suggest a mechanism for the antidepressive action of imipramine.