Histochemical Demonstration in Rat of Monoamine Oxidase Inhibition by β-Phenyl-Isopropyl Hydrazine

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Science  04 Aug 1961:
Vol. 134, Issue 3475, pp. 344
DOI: 10.1126/science.134.3475.344


A histochemical method for demonstration of monoamine oxidase activity was found to be almost as sensitive as a biochemical method when used for revealing total inhibition of monoamine oxidase in rat tissues after administration of β-phenyl-isopropyl hydrazine. The histochemical method is of special value in the study of monoamine oxidase inhibition in the complex structures of the brain.