Polynuclear Aromatic Hydrocarbons, Steroids and Carcinogenesis

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Science  11 Aug 1961:
Vol. 134, Issue 3476, pp. 386-387
DOI: 10.1126/science.134.3476.386


In addition to the electronic factors, there is a steric factor responsible for the carcinogenicity of polynuclear aromatic hydrocarbons. A carcinogenic polynuclear aromatic hydrocarbon must bear steric resemblance to steroids. One possible implication to this requirement for carcinogenicity is that these hydrocarbons may act on the same sites as steroid hormones.