Suppressor of Pyrimidine 3 Mutants of Neurospora and Its Relation to Arginine Synthesis

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Science  18 Aug 1961:
Vol. 134, Issue 3477, pp. 470-471
DOI: 10.1126/science.134.3477.470


The basis of the mutant phenotype of the pyr 3a strain of Neurospora appears to be the arginine sensitivity of an early step in pyrimidine synthesis. The effect of a suppressor mutation which renders pyr 3a pyrimidine-independent is to reduce arginine levels in the mycelium by its effect on ornithine transcarbamylase.