Rapid Development of Drug-Resistant Mutants of Poliovirus

Science  25 Aug 1961:
Vol. 134, Issue 3478, pp. 557
DOI: 10.1126/science.134.3478.557


Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.