Effects of 3-Methylcholanthrene and Phenobarbital on Amino Acid Incorporation into Protein

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Science  01 Sep 1961:
Vol. 134, Issue 3479, pp. 611-612
DOI: 10.1126/science.134.3479.611


Treatment of rats with methylcholanthrene and phenobarbital, two compounds known to enhance microsomal enzyme activity, stimulates the incorporation of free or soluble ribonucleic acid bound amino acid into proteins of cell-free liver preparations. Mitochondria, microsomes, and cell sap all contribute to the methylcholanthrene effect on the incorporation of free amino acid.