Stimulation of Uterine Contraction by Extracts of the Cockroach, Periplaneta

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Science  08 Sep 1961:
Vol. 134, Issue 3480, pp. 669-670
DOI: 10.1126/science.134.3480.669


Blood and extracts of gut of the American cockroach, Periplaneta americana, powerfully stimulate contractions of the isolated rat uterus. The contractions are characterized by long latency and a prolonged relaxation phase having superimposed rhythmic contractions. Evidence indicates that the stimulating factor is not acetylcholine, 5-hydroxytryptamine, histamine, or substance P. The active factor is heat labile and nondialyzable