10-Methoxyharmalan, a Potent Serotonin Antagonist Which Affects Conditioned Behavior

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Science  08 Sep 1961:
Vol. 134, Issue 3480, pp. 674-675
DOI: 10.1126/science.134.3480.674


10-Methoxyharmalan, an alkaloid obtained by the cyclodehydration of melatonin, itself a derivative of serotonin, is a more potent serotonin antagonist than harmaline and is only slightly less active than lysergic acid diethylamide. It has a similar, yet slightly greater, effect on behavior as that of harmaline and is the most potent serotonin derivative, so far tested, that affects the avoidance-escape behavioral reflex