Repression of Ornithine Transcarbamylase Protein Formation by Arginine

Science  15 Sep 1961:
Vol. 134, Issue 3481, pp. 737-738
DOI: 10.1126/science.134.3481.737


Arginine-repressed cells of Escherichia coli W do not form a protein immunologically related to ornithine transcarbamylase. This was determined by lack of cross-reactivity of repressed cell extracts with rabbit antisera prepared against purified ornithine transcarbamylase. The results indicate that arginine acts by blocking the synthesis of the entire enzyme-protein.