A Function for Tissue Mast Cells

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Science  22 Sep 1961:
Vol. 134, Issue 3482, pp. 842
DOI: 10.1126/science.134.3482.842


Experimental elimination of mast cells from the peritoneal tissues of the rat by distilled water treatment inhibited the increase of vascular permeability which normally follows a passively induced antigen-antibody reaction in peritoneal tissue. Thus mast cells may contribute to the initiation of inflammation which follows antigen-antibody reactions.