Reversal of Phenylalkylamine Tachyphylaxis by Norepinephrine

See allHide authors and affiliations

Science  13 Oct 1961:
Vol. 134, Issue 3485, pp. 1069-1070
DOI: 10.1126/science.134.3485.1069


Since the responses to "neurosympathomimetic amines" are reduced in the reserpinized animal and restored by norepinephrine administration, it was postulated that norepinephrine might also affect the development of their tachyphylaxis. We found that norepinephrine infusion restored, at least partially, certain tachyphylactic responses to amphetamine or ephedrine and fully prevented the development of tachyphylaxis to tyramine.