Explanation of Cocaine Desensitization of Blood Pressure Responses to Ephedrine

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Science  13 Oct 1961:
Vol. 134, Issue 3485, pp. 1075-1077
DOI: 10.1126/science.134.3485.1075-a


It is suggested that cocaine desensitizes ephedrine blood pressure responses by depletion of norepinephrine depots. This was shown by reversing cocaine desensitization through the administration of agents such as bretylium, which has a sparing effect on norepinephrine, and by the infusion of norepinephrine itself.