Passage of Saccharides from Cerebrospinal Fluid to Blood

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Science  03 Nov 1961:
Vol. 134, Issue 3488, pp. 1424
DOI: 10.1126/science.134.3488.1424


Saccharides with a molecular weight ranging from 182 to 50,000, which enter the cerebrospinal fluid at extremely slow rates when administered intravenously, all pass readily at similar rates from cerebrospinal fluid to blood after injection into a lateral cerebral ventricle. The mechanism of transfer appears to be a filtration of cerebrospinal fluid across a sieve-like boundary possibly located at the arachnoid villi.