Localization of Carbonic Anhydrase in the Nervous System

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Science  10 Nov 1961:
Vol. 134, Issue 3489, pp. 1524-1525
DOI: 10.1126/science.134.3489.1524


Single-cell analyses of carbonic anhydrase demonstrate that this enzyme is selectively concentrated in the glial and choroid cells of the rat brain. The nerve cells show a very low carbonic anhydrase activity. This specific localization supports the view that glial carbonic anhydrase is implicated in a mechanism for the active transport of chloride from the capillaries to the interstitial and cerebrospinal fluids.