Oral Proline Tolerance in Osteogenesis Imperfecta

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Science  10 Nov 1961:
Vol. 134, Issue 3489, pp. 1527-1528
DOI: 10.1126/science.134.3489.1527


Studies were carried out to test the hypothesis that a disturbance in proline or hydroxyproline metabolism, or both, is associated with defective collagen formation in osteogenesis imperfecta, a generalized disorder of connective tissue. Oral tolerance for proline in affected patients was lower than in comparable controls.