Genetical and Geographic Studies on Isoniazid Inactivation

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Science  10 Nov 1961:
Vol. 134, Issue 3489, pp. 1530-1531
DOI: 10.1126/science.134.3489.1530


Rapid and slow inactivators of isoniazid are homozygotes, and intermediate inactivators are heterozygotes. There is no dominance between the two alleles. The chasm between Eskimos and Caucasians in isoniazid metabolism is bridged by our investigation of the races in the Far East.