Depressant Agent from Walnut Hulls

See allHide authors and affiliations

Science  17 Nov 1961:
Vol. 134, Issue 3490, pp. 1617
DOI: 10.1126/science.134.3490.1617


Crushed unripe walnut hulls (Juglans nigra), when extracted with ether, yield an extract which sedates or at least depresses the movements of Daphnia magna, leopard frogs, perch, catfish, goldfish, mice, rats, and rabbits. One purified depressant compound, 5-hydroxy-1,4-naphthoquinone (juglone), has been isolated and tested on most of these species.