Glucose-6-Phosphate Dehydrogenase and Detoxification of Hydrogen Peroxide in Human Erythrocytes

Science  01 Dec 1961:
Vol. 134, Issue 3492, pp. 1756-1757
DOI: 10.1126/science.134.3492.1756


Human erythrocytes with deficient glucose-6-phosphate dehydrogenase levels are unable to maintain their levels of reduced glutathione in the presence of low-level, steady-state concentrations of hydrogen peroxide. This finding has bearing on the biochemical mechanisms of drug-induced hemolytic anemia.