Reports

Drug Resistance due to Inbreeding

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Science  08 Dec 1961:
Vol. 134, Issue 3493, pp. 1881-1882
DOI: 10.1126/science.134.3493.1881

Abstract

Inbred mice susceptible to audiogenic seizures were found to develop resistance to the protective effects of chlorpromazine and its analogs. It is proposed that the use of such inbred mice provides a unique new tool for studying drug mechanism and drug resistance.