Common Human Viruses as Carcinogen Vectors

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Science  15 Dec 1961:
Vol. 134, Issue 3494, pp. 1985-1986
DOI: 10.1126/science.134.3494.1985


Single doses of pairs of viruses and organic carcinogens (in amounts too small in themselves to induce tumors) were administered to male Swiss mice free of polyoma virus. Malignant tumors developed in groups of mice injected with five of the carcinogen-virus pairs. Prior immunization against the virus of a pair prevented tumor formation by that pair. Carcinogen binding by poliovirus 2 was demonstrated in vitro.