Action of Vasopressin on the Permeability of Mesentery

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Science  15 Dec 1961:
Vol. 134, Issue 3494, pp. 1987-1988
DOI: 10.1126/science.134.3494.1987


Contemporaneous movements of Rb86 cations and of P32 orthophosphate across isolated rabbit mesentery display kinetic patterns that are generally associated with passive diffusion. Vasopressin at a concentration of 100 milliunit/ml produced a significant increase in the permeability constant for P32 and at the same time a significant decrease in the permeability to Rb86. At lower hormone concentrations (0.1 milliunit/ml) the P32 response was less marked but still significant (P < .01), while the Rb86 effect was not (P > .05). Hyaluronidase did not mimic these actions of vasopressin.