Thermodilution Method for Measuring Cardiac Output of Rats by Using a Transistor Bridge

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Science  26 Jan 1962:
Vol. 135, Issue 3500, pp. 317-318
DOI: 10.1126/science.135.3500.317


Featuring an interlocking bridge amplifier, our new method measures cardiac output in animals from man to the rat, and one can perform many multiple assays with safety in the same animal with accuracy and reliability as reported, using room-temperature saline, whether the animal is in the normal or hyperthermic condition.