Simazine: Degradation by Corn Seedlings

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Science  02 Feb 1962:
Vol. 135, Issue 3501, pp. 373-374
DOI: 10.1126/science.135.3501.373


The herbicide 2-chloro-4,6-bis(ethylamino)-s-triazine (simazine) is converted to 2-hydroxy-4,6-bis(ethylamino)-s-triazine (hydroxysimazine) in vivo by corn seedlings and in vitro by corn extracts. Hydroxysimazine is considered to be a detoxified form of the herbicide. In vitro conversion was produced by reacting simazine with either a cyclic hydroxamate (2,4-dihydroxy-3-keto-7-methoxy-1,4-benzoxazine) or its glucoside. The latter compounds may mediate at least some of the in vivo conversion in corn.