Myo-inositol in the Biosynthesis of Streptomycin by Streptomyces griseus

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Science  02 Mar 1962:
Vol. 135, Issue 3505, pp. 734
DOI: 10.1126/science.135.3505.734


When myo-inositol is present in a growing culture of Streptomyces griseus the yield of streptomycin is increased, and the amount of carbon-14—from uniformly labeled glucose—incorporated into the streptidine and streptobiosamine moieties of streptomycin is lowered by 41 percent and 21.7 percent, respectively. These results present strong indirect evidence for the participation of myo-inositol or its metabolic products in streptidine biosynthesis.