Homograft Reaction in Mice: Effect of Urethane and Sublethal X-radiation

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Science  09 Mar 1962:
Vol. 135, Issue 3506, pp. 792-793
DOI: 10.1126/science.135.3506.792


Combined treatment of mice with urethane (a nucleic acid antagonist and mitotic inhibitor) plus sublethal x-radiation (500 rad) suppresses the homograft response to a degree considerably greater than that observed with this dose of x-rays alone. Thus, LAF1 mice receiving two injections of urethane plus 500 rad of x-radiation prior to grafting retained C3H mouse skin grafts for periods up to 60 days, with a mean graft survival time of 40 days, as compared with 18 days for mice exposed to 500 rad only.