Enhancement of Cesium-137 Excretion by Rats Treated with Acetazolamide

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Science  20 Apr 1962:
Vol. 136, Issue 3512, pp. 257-258
DOI: 10.1126/science.136.3512.257


Acetazolamide (10 mg/kg, intraperitoneally) increases the urinary excretion of cesium-137 in the rat. Meralluride (6.8 mg of Hg per kilogram, subcutaneously) blocks the effect of acetazolamide on the cesium-137 excretion without any influence on the urine volume and pH of the urine. This indicates that acetazolamide increases the urinary excretion of cesium-137 by increasing its secretion through the renal tubule in the same manner as it increases the excretion of potassium and rubidium-86.