Reports

Urinary Excretion of Amines in Phenylketonuria and Mongolism

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Science  08 Jun 1962:
Vol. 136, Issue 3519, pp. 879-880
DOI: 10.1126/science.136.3519.879

Abstract

Children with phenylketonuria excrete considerably less serotonin and tryptamine and somewhat less normetanephrine and p-tyramine than normal children. The excretion of these amines was not decreased in mongolism. Even during monoamine oxidase blockade, o-tyramine could not be detected in the urine of phenylketonurics. These findings are discussed in relation to the mental defect of phenylketonuria.