Localization of Two Genetic Factors to Different Areas of γ-Globulin Molecules

See allHide authors and affiliations

Science  15 Jun 1962:
Vol. 136, Issue 3520, pp. 979-980
DOI: 10.1126/science.136.3520.979


Gm(a) and Gm(b) factors are present in 7S γ-globulin molecules and absent in 19S γ-globulins, β2A-globulins and Bence-Jones proteins, whereas the Inv(b) factor was demonstrated in all four kinds of proteins. The Inv type was identical in isolated 7S and 19S γ-globulins of six normal sera. After papain splitting of 7S γ-globulin, Gm determining sites were present only in the fast (F) split product and Inv determining sites were present only in the slow (S).