Organ Cultures of Newborn Rabbit Skin Affected by Rabbit Papilloma Virus

See allHide authors and affiliations

Science  15 Jun 1962:
Vol. 136, Issue 3520, pp. 985-986
DOI: 10.1126/science.136.3520.985


Small fragments of newborn rabbit skin were exposed to papilloma virus and transferred to tissue culture. Control cultures were treated the same way, but without addition of the virus. These cultures were then followed for 4 weeks. During the first ten days, the number of epidermal elements declined gradually in both test and control cultures. From the 10th day on, however, a marked proliferation of the remaining epidermal cells was observed in cultures exposed to the virus, whereas no further changes were noticed in the control cultures.