Adrenocorticotropin Secretion Inhibited by Implantation of Hydrocortisone in the Hypothalamus

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Science  13 Jul 1962:
Vol. 137, Issue 3524, pp. 125-126
DOI: 10.1126/science.137.3524.125


Small quantities of crystalline hydrocortisone acetate, when implanted stereotaxically into the hypothalamus of rats, resulted in inhibition of compensatory adrenal hypertrophy and in adrenal atrophy. Similar implants of hydrocortisone in the pituitary gland, and of cholesterol in the hypothalamus, had no noticeable effect on the adrenals.