Chronic Effect of Tetanus Toxin Applied Locally to the Cerebral Cortex of the Dog

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Science  03 Aug 1962:
Vol. 137, Issue 3527, pp. 342-343
DOI: 10.1126/science.137.3527.342


Tetanus toxin injected into the cortex produces convulsions, neurological disability, and a strychnine-like discharging focus, appearing after a minimal latency of 2 days and lasting more than a month. Such a focus, apparently caused by a blockade of inhibitory synapses, does not demonstrate any major damage in microscopic studies.