Reports

Toxicity of Blood Clotting Factors

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Science  10 Aug 1962:
Vol. 137, Issue 3528, pp. 421-422
DOI: 10.1126/science.137.3528.421

Abstract

Pure bovine thrombin was separated from autoprothrombin C, and the lethal intravenous dose for mice weighing 25 g was 0.4 ml of a solution containing 50 units of thrombin per milliliter. Autoprothrombin C was not toxic alone, but with crude cephalin it was fatal. The clotting time of human plasma was only slightly accelerated by autoprothrombin C alone; the clotting time was as short as 5 seconds with a combination of autoprothrombin C and cephalin.

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