Protection of Rats against Adjuvant Arthritis by Bacterial Lipopolysaccharides

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Science  17 Aug 1962:
Vol. 137, Issue 3529, pp. 544-545
DOI: 10.1126/science.137.3529.544


Lipopolysaccharides from both gram-negative and gram-positive bacteria in incomplete adjuvant caused rats to become resistant to mycobacterial (complete) adjuvant arthritis. Lipopolysaccharides h protected rats when they were administered in adjuvant did not protect when administered in saline. Mycobacterial wax D in saline was protective, while in adjuvant it produced arthritis. The degree of stimulation of a common tissue reaction may determine whether the result is protection or disease.