Molecular Changes in Deoxyribonucleic Acid Induced by X-rays

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Science  24 Aug 1962:
Vol. 137, Issue 3530, pp. 607-609
DOI: 10.1126/science.137.3530.607


A chromatographic study of molecular changes in DNA after in vitro exposure to x-rays revealed little effect on the DNA macromolecule when either intact red cells of frog or DNA isolated from these cells was exposed to 1000 r. Increasing the dose to 10,000 r resulted in a significant shift from gradients of lower molecular weight to the higher gradients. These data suggest that cross-linking of DNA occurred at the higher radiation level.