Concurrent Morphological and Chemical Events in Staphylococcus aureus Exposed to Penicillin

Science  21 Sep 1962:
Vol. 137, Issue 3534, pp. 982-983
DOI: 10.1126/science.137.3534.982


Disruption and lysis as well as accumulation of cell-wall precursor material have been demonstrated in several strains of Gram-positive cocci as results of the action of penicillin. The concurrence of these phenomena in typically penicillin-sensitive bacteria lends further support to the hypothesis that penicillin exerts its antibiotic action through interference with the formation of cell walls.