Heart Autotransplantation: Effect on Myocardial Catecholamine and Histamine

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Science  05 Oct 1962:
Vol. 138, Issue 3536, pp. 40-41
DOI: 10.1126/science.138.3536.40


Complete excision and reimplantation of the canine heart is followed by a fall in myocardial norepinephrine to negligible levels. These decreases are at- tributable to the sympathetic denervation which necessarily accompanies the operative procedure. Myocardial histamine levels in survivors of this operation were not significantly different from those of normal dogs.