Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats

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Science  12 Oct 1962:
Vol. 138, Issue 3537, pp. 143-144
DOI: 10.1126/science.138.3537.143


An operant behavioral study on morphine addiction utilized a self-injection technique for giving intravenous injections to relatively unrestrained rats. The rate of self-injection varied inversely with the dose. Morphine was a reinforcer that produced almost immediate satiation.