Sarcoma 180 Inhibition by Combinations of 6-Thioguanine and Uracil Mustard

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Science  26 Oct 1962:
Vol. 138, Issue 3539, pp. 518-519
DOI: 10.1126/science.138.3539.518


Combinations of 6-thioguanine and uracil mustard produced greater inhibition of the growth of sarcoma 180 than that equivalent to the sum of the inhibitory effects caused by the optimum levels of the individual drugs. This potentiation was accomplished without marked weight loss by the host. Some possible biochemical mechanisms responsible for the drug synergy are discussed.