Maintenance of Globulin Levels in X-irradiated Rabbits after Immunization

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Science  26 Oct 1962:
Vol. 138, Issue 3539, pp. 519-520
DOI: 10.1126/science.138.3539.519


Rabbits were injected with antigen 24 hours after x-irradiation. Antibody titers were correlated with relative changes in gamma-beta globulin levels determined electrophoretically. Irradiated, immunized rabbits did not form detectable antibodies but had significantly greater globulin levels than non-immunized, irradiated controls. This relative difference occurred at the time nonirradiated, immunized rabbits were producing primary antibody.